Search results for " Experimental gerontology"

showing 4 items of 4 documents

Excessive daytime sleepiness is associated with an increased frequency of falls and sarcopenia.

2021

Background:\ud \ud This cross-sectional study aimed to examine associations between excessive daytime sleepiness (EDS) with falls and falls related conditions in older adults.\ud \ud Methods:\ud \ud To assess EDS, the Epworth Sleepiness Scale was used, with a score of ≥11/24 points indicating EDS. Number of falls and fall history (at least one) in the last year were recorded. Timed Up and Go test (TUG) was used to assess fall risk. Sarcopenia was defined by SARC-F tool. A grip strength score of the dominant hand, measured with a hand-grip dynamometer, less than 16 kg in females and 27 kg in males was accepted as dynapenia. Frailty status was defined by five dimensions including shrinking, e…

0301 basic medicineGerontologyMaleAgingSarcopeniaExcessive daytime sleepinessTimed Up and Go testDisorders of Excessive SomnolenceBiochemistry03 medical and health sciencesGrip strength0302 clinical medicineEndocrinologyGeneticsmedicineHumansMolecular BiologyGeriatric AssessmentPostural BalanceDepression (differential diagnoses)AgedPolypharmacyAged 80 and overbusiness.industryEpworth Sleepiness ScaleCell Biologymedicine.disease030104 developmental biologyCross-Sectional StudiesSarcopeniaDynapenia Excessive daytime sleepiness FallsFrailty SarcopeniaTime and Motion StudiesSoysal P. Smith L. Tan S. G. Capar E. Veronese N. Yang L. -Excessive daytime sleepiness is associated with an increased frequency of falls and sarcopenia.- Experimental gerontology ss.111364 2021Soysal P. Smith L. Tan S. G. Capar E. Veronese N. Yang L. -Excessive daytime sleepiness is associated with an increased frequency of falls and sarcopenia- 17 th EuGMS Athens Yunanistan 11 - 13 Ekim 2021 ss.3-4Marital statusAccidental FallsFemalemedicine.symptombusinesshuman activities030217 neurology & neurosurgeryExperimental gerontology
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The relationship between Polypharmacy and Trajectories of Cognitive Decline in People with Dementia: a large representative cohort study

2019

Polypharmacy, defined through the number of medications prescribed, has been linked to a range of adverse health outcomes in people with dementia. It is however unclear whether a numerical threshold of concurrently prescribed drugs is a suitable predictor for cognitive decline. We aimed to test associations between polypharmacy and both short-term (six months) and long-term (three years) cognitive trajectories in patients with incident dementia. Using data from a large mental health and dementia care database in South London, a cohort of 12,148 patients (mean age = 80.7 years, 61.1% female, mean MMSE = 18.6) clinically diagnosed with dementia was identified. We determined the number of medi…

Male0301 basic medicineGerontologyAgingCognitive declineBiochemistryCohort Studies03 medical and health sciencesCognitionCommunity care0302 clinical medicineEndocrinologyA large representative cohort study.- Experimental gerontology cilt.120 ss.62-67 2019 [Soysal P. Perera G. Isik A. Onder G. Petrovic M. Cherubini A. Maggi S. Shetty H. Molokhia M. Smith L. et al. -The relationship between polypharmacy and trajectories of cognitive decline in people with dementia]mental disordersGeneticsmedicineHumansDementiaCognitive DysfunctionCognitive declineassociations between polypharmacyMolecular BiologyAgedAged 80 and overPolypharmacypeople with dementia.Mini–Mental State Examinationmedicine.diagnostic_testbusiness.industryCognition; Cognitive decline; Community care; Dementia; PolypharmacyCognitionlong-term (three years)Cell BiologyMental Status and Dementia Testsmedicine.diseaseComorbidity030104 developmental biologyCohortPolypharmacyFemaleDementiabusinessshort-term (six months)030217 neurology & neurosurgeryCohort study
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Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries

2021

Background-\ud \ud The limited available literature suggests that sleep problems are linked to an increased risk of mild cognitive impairment (MCI). However, this association has been little studied to date in low-income settings.\ud \ud Objective-\ud \ud To investigate the association between sleep problems and MCI in a large sample of adults from six low-and middle-income countries (LMICs).\ud \ud Design-\ud \ud Cross-sectional.\ud \ud Setting-\ud \ud Study on Global Ageing and Adult Health (SAGE).\ud \ud Subjects-\ud \ud 32,715 individuals aged ≥50 years with preservation in functional abilities [age range 50–114 years; 51.7% females].\ud \ud Methods-\ud \ud MCI was defined using the Nat…

MaleAging*Low- and middle-income countries[SDV]Life Sciences [q-bio]Middle-aged adultsPsychological interventionSleep problemsLogistic regressionBiochemistry0302 clinical medicineEndocrinology*Sleep problemsPrevalence*Mild cognitive impairmentMedicine030212 general & internal medicineCognitive impairmentMorning*Older adultsAged 80 and overLow- and middle-income countriesMiddle AgedSleep in non-human animals3. Good healthOlder adultsFemaleSleep Wake Disorders*DementiaOdds03 medical and health sciencesmental disordersGeneticsHumansDementiaCognitive DysfunctionDeveloping CountriesMolecular BiologyAged*Middle-aged adultsbusiness.industryMild cognitive impairmentCell Biologymedicine.diseaseCross-Sectional StudiesAgeingSmith L. Shin J. I. Jacob L. Carmichael C. López Sánchez G. F. Oh H. Butler L. T. Barnett Y. Pizzol D. Tully M. A. et al. -Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries.- Experimental gerontology ss.111513 2021DementiaMild cognitive impairment Dementia Sleep problems Low- and middle-income countries Middle-aged adults Older adultsbusiness030217 neurology & neurosurgeryDemographyExperimental Gerontology
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Mild cognitive impairment is associated with fall-related injury among adults aged ≥65 years in low- and middle-income countries.

2021

Abstract Objectives There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa). Design Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Methods The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria, and information on past 12-month fall-related injury was also collected. Multivariable l…

Male0301 basic medicineChinaAgingIndiaPoison controlLogistic regressionGhanaBiochemistrySuicide preventionOccupational safety and healthRussiaOdds*Low-and-middle-income countriesSouth Africa03 medical and health sciencesOlder adults.0302 clinical medicineEndocrinologyRisk FactorsFall-related injuryInjury preventionmental disorders*Fall-related injuryPrevalenceGeneticsHumansMedicine*Mild cognitive impairmentCognitive DysfunctionDeveloping CountriesMexicoMolecular BiologyAged*Older adultsbusiness.industryConfoundingMild cognitive impairmentHuman factors and ergonomicsSmith L. Jacob L. Kostev K. Butler L. Barnett Y. Pfeifer B. Soysal P. Grabovac I. López-Sánchez G. F. Veronese N. et al. -Mild cognitive impairment is associated with fall-related injury among adults aged ≥65 years in low- and middle-income countries.- Experimental gerontology ss.111222 2020Cell BiologyCross-Sectional Studies030104 developmental biologyLow-and-middle-income countrieAccidental FallsFemalebusiness030217 neurology & neurosurgeryDemography
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